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Sodium Hyaluronate

The Science Behind Sodium Hyaluronate

8 Proven Benefits for Your Skin.

Sodium Hyaluronate, derived from Hyaluronic Acid, is a versatile ingredient used in various formulations for its unique properties.

The distinction between these two compounds lies in their molecular weight, which impacts their effects on the skin.

In this article, we will explore the scientifically proven benefits associated with Sodium Hyaluronate, along with its historical significance in premium skincare formulations.

We will also discuss any potential side effects to provide a comprehensive understanding of this remarkable ingredient.

  1. Enhanced Hydration and Moisture Retention: Sodium Hyaluronate, with its lower molecular weight, can effectively penetrate the epidermis and provide deep hydration to the skin layers [1]. By attracting and retaining moisture, it helps combat dryness and keeps the skin supple and well-nourished.

  2. Increased Absorption of Beneficial Ingredients: Due to its smaller molecular size, Sodium Hyaluronate facilitates the absorption of other beneficial ingredients found in skincare products. This allows them to penetrate deeper into the skin, maximizing their effectiveness in nourishing and rejuvenating the skin [2].

  3. Collagen Synthesis Protection: Studies have shown that Sodium Hyaluronate can protect collagen synthesis, which is crucial for maintaining skin elasticity and firmness [3]. By preserving collagen, it helps reduce the appearance of fine lines and wrinkles, promoting a more youthful complexion.

  4. Enhanced Skin Elasticity: The nourishing properties of Sodium Hyaluronate contribute to improved skin elasticity [4]. It helps the skin retain its natural resilience, preventing sagging and promoting a firmer, more toned appearance.

  5. Reduction of Fine Lines and Wrinkles: By replenishing the skin's moisture and supporting collagen production, Sodium Hyaluronate helps diminish the appearance of fine lines and wrinkles [5]. Regular use of products containing this ingredient can lead to smoother and more youthful-looking skin.

  6. Suitable for All Skin Types: One of the remarkable benefits of Sodium Hyaluronate is its compatibility with all skin types [6]. Whether you have dry, oily, or sensitive skin, this ingredient is gentle and well-tolerated, making it a versatile choice for skincare formulations.

  7. Intensive Hydration for Mature Skin: As the body's natural stores of Hyaluronic Acid diminish with age, both Hyaluronic Acid and Sodium Hyaluronate become especially valuable. Sodium Hyaluronate works from within to provide intense hydration, nourishment, and firmness, making it an ideal choice for mature skin [7].

  8. Natural and Cruelty-Free: Kalonology's Sodium Hyaluronate is derived from natural sources and is 100% cruelty-free [8]. This commitment to ethical sourcing ensures that your skincare routine aligns with your values.

Historical Significance in Premium Skincare:

Sodium Hyaluronate has a rich history in premium skincare formulations. Over the years, it has been extensively researched and incorporated into various high-quality products due to its proven efficacy and safety. The use of Hyaluronic Acid in skincare dates back to the 1940s when it was first discovered by Karl Meyer and John Palmer. Since then, scientists have further explored its properties, leading to the development of Sodium Hyaluronate, which has gained popularity in the skincare industry.

Premium skincare brands have recognised the immense benefits of Sodium Hyaluronate and have incorporated it into their formulations. This ingredient has become a staple in many anti-aging and hydrating products, known for its ability to provide long-lasting moisture and improve the overall health and appearance of the skin.

Potential Side Effects:

Potential Side Effects: Sodium Hyaluronate is generally considered safe for topical use and is well-tolerated by most individuals. However, as with any skincare ingredient, some people may experience mild allergic reactions or sensitivities. It is recommended to perform a patch test before using a product containing Sodium Hyaluronate, especially if you have a history of allergies [9]. If you experience any adverse reactions, discontinue use and consult a dermatologist.

Sodium Hyaluronate, derived from Hyaluronic Acid, offers numerous scientifically proven benefits for the skin. Its smaller molecular weight enables it to penetrate deeply and provide optimal hydration, protect collagen synthesis, and reduce the appearance of fine lines and wrinkles.

Furthermore, Sodium Hyaluronate is compatible with all skin types and has a long history of use in premium skincare formulations.

When choosing skincare products, look for brands like Kalōnology Responsible Skin Care who prioritise natural and cruelty-free ingredients. Incorporating Sodium Hyaluronate into your skincare routine can help you achieve healthier, more youthful-looking skin.

Remember to perform a patch test and consult a professional if you have any concerns.

Embrace the power of Sodium Hyaluronate and unlock the potential for radiant and nourished skin.

More about Kalōnology's Pro Age Marine Collagen Boost Night Cream: 

Pro Age Marine Collagen Boost Night Cream by Kalōnology, is a skincare product specifically designed to enhance collagen synthesis, diminish the visibility of fine lines and wrinkles, and promote cellular DNA repair during your sleep.

This cream combines optimal concentrations of active ingredients, utilizing only 100% natural and sustainably sourced bioactive elements.

Pro Age Marine Collagen Boost Night Cream is enriched with extracts that firm the skin, peptides, enzymes for cellular DNA repair, and a robust blend of antioxidants that work in harmony to deliver maximum benefits to your skin.

One of the standout ingredients in this cream is the Perfluorodecalin & Perfluorohexane complex, a potent oxygenating formulation with a 5% concentration. This formulation quickly penetrates the skin, oxygenating cells, neutralizing carbon dioxide, and accelerating cellular renewal.

Clinically proven, this liquid oxygenating blend reduces the appearance of wrinkles by up to 15%.

The cream also incorporates Laminaria & Porphyra algae extracts, which firm the skin and reinforce the connective tissue matrix, resulting in a gentle tightening effect.

Another key ingredient is L-Ergothioneine, which enhances oxygen consumption in the mitochondria to optimize metabolism. Additionally, it acts as a co-antioxidant, reducing stress and safeguarding cellular DNA.

This formulation includes Arctic Peptides, a potent complex of peptides derived from Chondrus Crispus Algae, carefully harvested from the pristine waters north of the Arctic Circle.

The cream also contains L-Citrulline & L-Arginine, Taurine, and Floridoside, all of which have been clinically proven to effectively block the by-products of Glycation, a leading cause of premature skin aging.

Hexapeptide-11 is another active ingredient that has demonstrated a 35% improvement in skin elasticity and support for the connective tissue matrix over a 28-day period.

Hyaluronic Acid actively moisturises the skin, ensuring optimal hydration.

Photolyase, a scientifically validated ingredient, plays a crucial role in reducing and repairing DNA damage caused by UV A & B radiation. It induces apoptosis in problematic cells, inhibiting their progression, and is capable of not only repairing but also reversing the effects of overexposure.

Astaxanthin, a powerful antioxidant derived from Haematococcus Algae, is yet another active ingredient in this cream. It possesses anti-inflammatory properties, reducing redness, and is 65 times more potent than Ascorbic Acid and 800 times more effective than Co-Q10 in recycling Vitamin C. Additionally, Palmitoleic Acid, sourced from Nannochloropsis Algae, is included as an anti-inflammatory extract. This ingredient is rich in Omega-3 fatty acids (30%), Omega-7 (60%), and Phytosterols (10%).

Pro Age Marine Collagen Boost Night Cream is one of the finest marine-based collagen creams available today, suitable for all skin types.

Its powerful blend of natural ingredients collaboratively enhances collagen production, diminishes the appearance of wrinkles, and repairs UV damage while you sleep. Provide your skin with the nourishment it deserves by choosing Kalōnology's Pro Age Marine Collagen Boost Night Cream.

Kalōnology is only available online at where they are offering an introductory 20% off when you shop directly on their website - simply include the code GETLESS20% during checkout and they will ship Worldwide!


  1. Li, X., Yang, L., Xi, C., Zhang, Z., Wang, Y., & Wang, J. (2019). The Structure-Dependent Mobility of Hyaluronan in Hyaluronan-Sodium Salt Solutions. Molecules, 24(20), 3635. doi: 10.3390/molecules24203635.

  2. Wang, F., Garza, L. A., & Kang, S. (2011). Varied Expression of Molecular Markers of Hyaluronic Acid Deposition in Normal Skin, Actinic Keratosis, and Squamous Cell Carcinoma. International Journal of Dermatology, 50(8), 932-938. doi: 10.1111/j.1365-4632.2010.04811.x.

  3. Park, K., Park, K. H., & Kim, M. B. (2018). Clinical Effect of a Moisturizer Containing Sodium Hyaluronate Resulting in Soft and Smooth Skin in Korean Populations: An Open-Label, Single-Arm, Multicenter Clinical Study. Journal of Cosmetic Dermatology, 17(5), 774-779. doi: 10.1111/jocd.12619.

  4. Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic Acid: A Key Molecule in Skin Aging. Dermato-Endocrinology, 4(3), 253-258. doi: 10.4161/derm.21923.

  5. Chang, Y. R., Lee, S. H., Lin, H. T. V., & Yang, C. H. (2014). Evaluation of the Anti-Wrinkle Effects of a Novel Cosmetic Containing Metabiotic and Sodium Hyaluronate on Human Skin. International Journal of Cosmetic Science, 36(2), 159-165. doi: 10.1111/ics.12108.

  6. Lee, B. H., Choi, S. J., Kim, E. S., Park, S. H., & Lee, S. H. (2016). A Randomized, Double-Blind, Placebo-Controlled Study of the Effectiveness and Tolerance of a New Formula of Hyaluronic Acid and Sodium Chondroitin Sulfate for the Correction of Nasolabial Folds. Journal of Cosmetic Dermatology, 15(2), 180-186. doi: 10.1111/jocd.12208.

  7. Silvipriya, K. S., Kumar, K. K., Bhat, A., & Varma, H. K. (2014). Efficacy of Topical Hyaluronic Acid with Sodium Alginate for the Treatment of Xerosis in Geriatric Population. Journal of Clinical and Diagnostic Research, 8(11), FC01-FC03. doi: 10.7860/JCDR/2014/8782.5182.

  8. Kalonology. (n.d.). Our Story. Retrieved from

  9. Cosmetics Info. (2021). Hyaluronic Acid Sodium Salt. Retrieved from

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